1. TIMPs
   The tissue metalloproteinase inhibitor family helps inhibit cartilage degradation, improve osteoarthritis and slow down the inflammatory response in joints.
   
   
2. IGFBPs
   The insulin-like growth factor binding protein family plays an important role in the growth regulation of vertebrates and helps increase regeneration and repair capabilities. Research has proven that it helps repair knee cartilage and inhibits inflammation.
   
   
3. TGFβ
   Transforming growth factor-β, stimulates the formation of cartilage, slows down chronic inflammation of joints, etc.
   
   
4. BMP Family
   Bone morphogenetic protein family. Cytokines with ectopic osteogenic ability can stimulate mesenchymal stem cell tissue to differentiate and repair ligaments, tendons, nerve tissue, chondrocytes and osteoblasts. The ingredients are proven to be effective in bone synthesis and anti-inflammation. BMP2 can increase the ability of tendon-bone bonding; BMP7 can increase the ability of tendon-bone bonding and regenerate knee cartilage. Both BMP2 and BMP2 have been proven to contribute to knee cartilage repair and inhibit inflammation; BMP9 has been proven to contribute to knee joint cartilage defects. of repair.
   
   
5. VEGF
   Vascular endothelial growth factor. It can promote angiogenesis, help improve blood circulation around joints and accelerate tissue recovery.

1. Therapeutic effect
   Reduce the pain of degenerative joints, control acute inflammation, and promote the growth of cartilage and bone tissue.
   
   
2. Tendon repair
   Promote the replenishment of ligament collagen, strengthen muscle membrane endurance, and increase the connection between tendons/ligaments and bones.
   
   
3. Tissue Regeneration
   Promote the growth of ruptured muscle bundles and relieve muscle fibrosis, stabilize the connections between muscle cells, and repair pain symptom.

   Induces cartilage regeneration, stimulates bone regeneration, and accelerates the repair of defective parts.

British Precision Targeting Technology:
Accurately target lesions to reduce waste and interference

Taiwan’s exclusive intelligent variation point control design:
To avoid the occurrence of other ineffective reactions and affect efficacy

International Leading Technology Application:
Effective design and application in various fields to benefit the needs of all ethnic groups

Knee: degenerative knee arthritis, semilunar valve cartilage laceration, ligament injury, patellar chondromalacia, tendonitis, synovial fluid Bursitis

Shoulder: Rotator tendonitis or rupture, biceps tendonitis, frozen shoulder, subdeltoid bursitis, shoulder labrum cartilage tear

Ankle and sole: medial and lateral ligament strain or rupture, disjunct chondritis, sole fracture or dislocation, plantar fasciitis Achilles tendon tear

Common pain points and reflex pain points: Stiff neck, head and neck pain, shoulder pain, upper limb pain, back pain, waist pain, lower limbs sore

1. Professional papers
   Research literature related to joint degeneration published in international journals provides a wealth of academic references.
   
   
2. Case Study
   Case studies by medical experts from various countries explore treatment options for joint degeneration from different angles.
   
   
3. Transnational cooperation
   International collaborative research has brought about breakthrough technologies and treatments, and opened up research in the field of joint degeneration category.

References:

1. 1. Bach, L. A. (2018). 40 YEARS OF IGF1: IGF-binding proteins. Journal of Molecular Endocrinology, 61(1), T11-T28.
   2. Schwarting, T., Schenk, D., Frink, M., Benölken, M., Steindor, F., Oswald, M., Ruchholtz, S., & Lechler, P. (2016). Stimulation with bone morphogenetic protein-2 (BMP-2) enhances bone-tendon integration in vitro. Connective tissue research, 57(2), 99–112.
   3. Schwarting, T., Benölken, M., Ruchholtz, S., Frink, M., & Lechler, P. (2015). Bone morphogenetic protein-7 enhances bone-tendon integration in a murine in vitro co- culture model. International orthopaedics, 39(4), 799–805.
   4. Shah, S. S., & Mithoefer, K. (2020). Current Applications of Growth Factors for Knee Cartilage Repair and Osteoarthritis Treatment. Current reviews in musculoskeletal medicine, 13</i >(6), 641–650.
   5. Liu, X., Du, M., Wang, Y., Liu, S., & Liu, X. (2018). BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway. Experimental and therapeutic medicine, 16(6), 4623–4631.
   6. Cook, S. D., Patron, L. P., Salkeld, S. L., & Rueger, D. C. (2003). Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs. The Journal of bone and joint surgery. American volume, 85-A Suppl 3, 116–123.